NUTRITIONAL BIOCHEMISTRY -II

Paper Code: 
24CFSN801
Credits: 
4
Contact Hours: 
4.00
Max. Marks: 
100.00
Objective: 

This course will enable the students to –

  1. Understand the biochemical role of vitamins and minerals and their disorders and imbalances.
  2. Understand toxicity in the body and role of antioxidants in detoxification of the body.

 

Course Outcomes: 

Course

Learning outcome

(at course level)

Learning and teaching strategies

Assessment Strategies 

Course Code

Course

Title

      

 

2                              24CFSN801

                                  Nutritional

                                               Biochemistry II 

                                    (Theory)

 

CO115: Appraise the constituents, biochemistry, functions and disorders of DNA and RNA

CO116: Determine the role of hormones in metabolic regulation 

CO117: Assess the biochemical role of antioxidants and vitamins

CO118: Assess the biochemical role of minerals

CO119: Analyse the mechanism of detoxification and role of xenobiotics in health

CO120: Contribute effectively in course specific interaction

Approach in teaching:

Interactive Lectures, Discussion, Power Point Presentations, Informative videos, group discussion

 

Learning activities for the students:

Self learning assignments, Effective questions, presentations, Field trips

Quiz, Poster Presentations,

Power Point Presentations, Individual and group projects,

Open Book Test, Semester End Examination, discussion, demonstration

 

 

 

12.00
Unit I: 
Nucleic acid Chemistry
  • Composition, classification of purines, pyrimidines, Nucleosides, Nucleotides,
  • Structure and properties of DNA and RNA
  • Functions of  DNA and RNA
  •  DNA replication, RNA transcription and translation.   
  • Mutations – Basic concept
  • Genetic Disorders

 

12.00
Unit II: 
Hormones
  • Definition, classification, mode of action, Chemistry and functions of Thyroxine, Insulin, Catecholamines
  • Disorders associated with the hormones – Thyroxine, Insulin and catecholamines
  • Homeostasis of blood glucose
  • Hormones related to PCOS
  • Endocrine causes of hypertension

 

12.00
Unit III: 
Antioxidants and Vitamins

Antioxidants

  • Antioxidants and free radicals; role of O2 free radicals; production of O2 free radicals; physiological mechanisms to limit free radical damage; free radical in human pathology and disease
     
  • Classification and Biochemical roles of vitamins –
  • Fat soluble vitamins - A, D, E, K
  • Water soluble vitamins B1,B2,B3,B6,B12,Pantothenic acid

 

12.00
Unit IV: 
Minerals

Biochemical roles of 

·       Macro minerals: Calcium, phosphorous, magnesium, sodium, potassium and chloride

·       Micro Minerals: Iron, copper, zinc, manganese, iodine, fluoride

Trace Minerals: Selenium, cobalt, chromium, vanadium, silicon, nickel

12.00
Unit V: 
Detoxification of Foreign Compounds - metabolism of xenobiotics
  • Phase I, Phase II and Phase III
  • Regulation of detoxification
  • Diet and Nutrients that support detoxification
  • Inhibition of detoxifying enzymes

 

Essential Readings: 
  • Rao, K.R. (1986) Textbook of Biochemistry, III Edition. Prentice Hall of India Pvt. Ltd., New Delhi.
  • Murray, R.K. Granner, P.A. Mayes, V.W. Rodwell (1988) Harper’s Biochemistry. 21st Edition. Prentice Hall of Australia Pvt. Ltd.
  • Lehninger, A.L. (1987) Principles of Bio-chemistry – CBS Publishers and Distributors
  • West, E.S. Todd W.R. Mason, H.S. and Van Bruggen J.T (1974) 4th Ed. Text Book of Biochemistry, Amerind Publishing Co. Pvt. Ltd.
  • Harper, H.A. Review of Physiological Chemistry. Lange medical Library
  • White, A., Handler, P. and Smith, E.L. Principles of Biochemistry . W. B. Saunders Book Co. Philadelphia.

 

References: 
  • Berg, Jeremy Mark, Tymoczko, John L and Stryer. (2002). Biochemistry 5th ed. New York. W.H. Freeman and Co.
  • Brody Tom. (2004). Nutritional Biochemistry 2nd ed. New Delhi. Elsevier/Reed. Elsevier. India Pvt. Ltd.
  • Chatterjee, M.N. Shinde and Rana. (2005). Textbook of Medical Biochemistry, 6th ed. New Delhi, Jaypee Brothers. Medical Publisher.
  • DandekarSucheta P. (2002). Medical Biochemistry (Prep Manual for U.G.) 2nd ed. New Delhi B-1 Churchill Livingstone Pvt. Ltd.
  • Rastogi S.C. (1993). Biochemistry New Delhi, Tata McGraw Hill Publishing Co. Ltd.Definition, classification of lipids. Simple, Compound and derived
  • Kahn Conn, E.E. and Stump, P.K. Outlines of Biochemistry. Willey Eastern Pvt. Ltd. New Delhi 
  • Stryer L. (1995) Biochemistry Freeman WH & Co.
  • Sundararaj, P and Siddhu A (1995) Qualitative tests and Quantitative Procedures in Biochemsitry.
  • Varley H. Gowenlock, A.H. and Bell, M (1980) 5th Ed. Practical and Clinical Chemistry Vol. I William Heinemann Medical Book Ltd.

 

E RESOURCE: 

 

 

Academic Year: 
2024-2025
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