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CANCER BIOLOGY
Paper Code:
HFN 143(E)
Credits:
04
Contact Hours:
60.00
Max. Marks:
100.00
Objective:
• To understand the causes, risk factors and underlying changes in the body during cancer
• To have an insight into prevention, treatment and management of the disease and its complications
12.00
Unit I:
UNIT 1
• Biology of Cancer
a) Cell cycle and cancer, the nature and types of cancer
b) Cellular oncogenes and Tumor suppressor genes: DNA viruses, retroviruses, proto oncogenes, tumor suppressor genes, pRb and control of the cell cycle clock, p53 and apoptosis
c) Tumor immunology: immune mediated disease (hypersensitivity and autoimmunity)
12.00
Unit II:
UNIT 2
• Toxicity at Cellular level and Enzymology Involved
a) Mechanism of toxicity: toxicity of O2, xenobiotics, mutagens and carcinogens
b) Multistage carcinogenesis: chemical carcinogens-genotoxic, nongenotoxic and inorganic carcinogens
c) Biotransformation of xenobiotics through liver detoxification (Phase I and II)
d) Mechanism of repair (molecular and cellular), toxicity resulting from inappropriate repair
12.00
Unit III:
UNIT 3
• Principles of Cancer Treatment
a) Natural history of cancer therapy, ethical and philosophical issues
b) Treatment available: surgery, radiation, chemotherapy, biological therapy, gene therapy
12.00
Unit IV:
UNIT 4
• Principles of Cancer Screening and Chemoprevention of Cancer
a) Screening of cancer and the biases of screening, screening of specific cancers
b) Chemoprevention: Chemopreventive agents from natural products, preclinical animal model selection, phytopharmaceuticals in cancer chemoprevention
12.00
Unit V:
UNIT 5
• Test Systems/Assays used in Cancer
a) Carcinogenicity assessment: short term tests for mutagenicity, chronic testing for carcinogenicity and transgenic animals in carcinogenicity assessment
b) Assays for detecting genetic alterations: DNA damage and repair assays, genetic alteration in mammals, mammalian cytogenetic assays, germ cell mutagenesis
c) New approaches to genetic toxicology
Essential Readings:
• Casarett & Doull’s (7th ed ) Toxicology: The basic Science of Poisons, Curtis D. Klassen
• Haskell: Caner Treatment (4th Ed), W.B Saunders Company, Mc. Graw Hill.
• Pecckham, Pinedo and Veronesi: Oxford Textbook of Oncology,Vol:1 and 2.
• Chemoprevention of Cancer and DNA Damage by Dietary Factors: Edited by Siegfried Knasmüller, David M. DeMarini, Ian Johnson, and Clarissa Gerhäuser. WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Academic Year:
