This course will enable the students to –
imbalances.
Nucleic acid Chemistry
Structures of purines, pyrimidines, Nucleocides, Nucleotides,
Metabolism of Purine and Pyrimidine,
Disorders of purine metabolism
Composition, classification, structure and properties of DNA and RNA; functions of nucleic acids - DNA replication and RNA transcription.
Hormones
Definition, classification, mode of action, Chemistry and functions of Thyroxine, Insulin, Catecholamines
Disorders associated with the hormones
Antioxidants
Antioxidants and free radicals; role of O2 free radicals; production of O2 free radicals; physiological mechanisms to limit free radical damage; free radical in human pathology and disease.
Vitamins
Classification and Biochemical role of vitamins –
Minerals
Biochemical roles 0f
Detoxification of Foreign Compounds - metabolism of xenobiotics
Phase I, Phase II and Phase III
Regulation of detoxification
Diet and Nutrients that support detoxification
Inhibition of detoxifying enzymes
1. Rao, K.R. (1986) Textbook of Biochemistry, III Edition. Prentice Hall of India Pvt. Ltd., New Delhi.
2. Murray, R.K. Granner, P.A. Mayes, V.W. Rodwell (1988) Harper’s Biochemistry. 21st Edition. Prentice Hall of Australia Pvt. Ltd.
3. Lehninger, A.L. (1987) Principles of Bio-chemistry – CBS Publishers and Distributors
4. West, E.S. Todd W.R. Mason, H.S. and Van Bruggen J.T (1974) 4th Ed. Text Book of Biochemistry, Amerind Publishing Co. Pvt. Ltd.
5. Harper, H.A. Review of Physiological Chemistry. Lange medical Library
6. White, A., Handler, P. and Smith, E.L. Principles of Biochemistry . W. B. Saunders Book Co. Philadelphia.