ADVANCED NUTRITIONAL BIOCHEMISTRY II (Theory)

Paper Code: 
24HFN221
Credits: 
04
Contact Hours: 
60.00
Max. Marks: 
100.00
Objective: 

This course will enable the students to –

  1. Understand the biochemical role of vitamins and minerals and their disorders and imbalances.
  2. Understand toxicity in the body and role of antioxidants in detoxification of the body.
Course Outcomes: 

Course

Learning outcome

(at course level)

Learning and teaching strategies

Assessment Strategies

Course Code

Course

title

24HFN221

Advanced Nutritional Biochemistry II

(Theory)

COFN41: Appraise the constituents, biochemistry, functions and disorders of

DNA and RNA

COFN42: Correlate the role of hormones

with metabolic regulation

COFN43: Develop an understanding of

biochemical role of antioxidants and vitamins

COFN44: Assess the biochemical role

of minerals

COFN45: Develop an understanding about detoxification of various compounds and the knowledge of xenobiotics and its role in health.

COFN46: Contribute effectively in course

specific interaction

 

Approach in teaching:

Interactive Lectures,

Discussion, Power Point

Presentations, Informative

videos, group discussion

 

Learning activities for the

students:

Self learning assignments,

Effective questions,

presentations, Field trips

 

 

 

 

Quiz, Poster

Presentations,

Power Point

Presentations,

Individual and group

projects,

Open Book Test,

Semester End

Examination,

discussion,

demonstration

 

12.00
Unit I: 
Nucleic acid Chemistry
  • Composition, classification of purines, pyrimidines, Nucleosides, Nucleotides,
  • Structure and properties of DNA and RNA
  • Functions of  DNA and RNA
  •  DNA replication, RNA transcription and translation.  
  • Mutations – Basic concept
  • Genetic Disorders

 

12.00
Unit II: 
Hormones
  • Definition, classification, mode of action, Chemistry and functions of Thyroxine, Insulin, Catecholamines
  • Disorders associated with the hormones – Thyroxine, Insulin and catecholamines
  • Homeostasis of blood glucose
  • Hormones related to PCOS
  • Endocrine causes of hypertension

 

12.00
Unit III: 
Antioxidants and Vitamins

·         Antioxidants and free radicals; role of O2 free radicals; physiological mechanisms to limit free radical damage; free radical in human pathology and disease

·         Classification and Biochemical roles of vitamins –

·         Fat soluble vitamins - A, D, E, K

·         Water soluble vitamins B1,B2,B3,B6,B12,Pantothenic acid 

12.00
Unit IV: 
Minerals

     Biochemical roles of

·         Macro minerals: Calcium, phosphorous, magnesium, sodium, potassium and chloride

·         Micro Minerals: Iron, copper, zinc, manganese, iodine, fluoride

·         Trace Minerals: Selenium, cobalt, chromium, vanadium, silicon, nickel

12.00
Unit V: 
Detoxification of Foreign Compounds - metabolism of xenobiotics
  • Phase I, Phase II and Phase III
  • Regulation of detoxification
  • Diet and Nutrients that support detoxification
  • Inhibition of detoxifying enzymes

 

Essential Readings: 
  1. Rao, K.R. (1986) Textbook of Biochemistry, III Edition. Prentice Hall of India Pvt. Ltd., New Delhi.
  2. Murray, R.K. Granner, P.A. Mayes, V.W. Rodwell (1988) Harper’s Biochemistry. 21st Edition. Prentice Hall of Australia Pvt. Ltd.
  3. Lehninger, A.L. (1987) Principles of Bio-chemistry – CBS Publishers and Distributors
  4. West, E.S. Todd W.R. Mason, H.S. and Van Bruggen J.T (1974) 4th Ed. Text Book of Biochemistry, Amerind Publishing Co. Pvt. Ltd.
  5. Harper, H.A. Review of Physiological Chemistry. Lange medical Library
  6. White, A., Handler, P. and Smith, E.L. Principles of Biochemistry . W. B. Saunders Book Co. Philadelphia.

 

References: 
  1. Berg, Jeremy Mark, Tymoczko, John L and Stryer. (2002). Biochemistry 5th ed. New York. W.H. Freeman and Co.
  2. Brody Tom. (2004). Nutritional Biochemistry 2nd ed. New Delhi. Elsevier/Reed. Elsevier. India Pvt. Ltd.
  3. Chatterjee, M.N. Shinde and Rana. (2005). Textbook of Medical Biochemistry, 6th ed. New Delhi, Jaypee Brothers. Medical Publisher.
  4. DandekarSucheta P. (2002). Medical Biochemistry (Prep Manual for U.G.) 2nd ed. New Delhi B-1 Churchill Livingstone Pvt. Ltd.
  5. Rastogi S.C. (1993). Biochemistry New Delhi, Tata McGraw Hill Publishing Co. Ltd.Definition, classification of lipids. Simple, Compound and derived
  6. Kahn Conn, E.E. and Stump, P.K. Outlines of Biochemistry. Willey Eastern Pvt. Ltd. New Delhi
  7. Stryer L. (1995) Biochemistry Freeman WH & Co.
  8. Sundararaj, P and Siddhu A (1995) Qualitative tests and Quantitative Procedures in Biochemsitry.
  9. Varley H. Gowenlock, A.H. and Bell, M (1980) 5th Ed. Practical and Clinical Chemistry Vol. I William Heinemann Medical Book Ltd.

 

 

Academic Year: 
2024-2025
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