ADVANCED NUTRITIONAL BIOCHEMISTRY II (THEORY)

Paper Code: 
HFN 221
Credits: 
03
Contact Hours: 
45.00
Max. Marks: 
100.00
Objective: 
This course will enable the students to –
• Understand biochemical basis of nutrition and health.
• Understand biochemical role of vitamins and minerals and there disorders and
imbalances.
• Toxicity in the body and detoxification of the body 
• Role of antioxidants in detoxifying the body
• Become proficient for specialization in nutrition
9.00
Unit I: 
Nucleic acid Chemistry
Structures of purines, pyrimidines, Nucleocides, Nucleotides,
 Metabolism of Purine and Pyrimidine,
 Disorders of purine metabolism
Composition, classification, structure and properties of DNA and RNA; functions of nucleic acids - DNA  replication and  RNA transcription.   
 
9.00
Unit II: 
Hormones
Definition, classification, mode of action, Chemistry and functions of Thyroxine, Insulin, Catecholamines
Disorders associated with the hormones
 
Antioxidants
Antioxidants and free radicals; role of O2 free radicals; production of O2 free radicals; physiological mechanisms to limit free radical damage; free radical in human pathology and disease.
 

 

9.00
Unit III: 
Vitamins
Classification and Biochemical role of vitamins –
• Fat soluble vitamins A, D, E, K, C and B-complex.
• Water soluble vitamins B1,B2,B3,B6,B12,Pantothenic acid,
9.00
Unit IV: 
Minerals
Biochemical roles 0f 
• Macro minerals: Calcium, Phosporous, magnesium, sodium, potassium and chloride
• Micro Minerals: Iron, copper, zinc, manganese, iodine, fluoride
• Trace Minerals: Selenium, cobalt, chromium, vanadium, silicon, nickel
 
9.00
Unit V: 
Detoxification of Foreign Compounds - metabolism of xenobiotics
Phase I, Phase II and Phase III
Regulation of detoxification
Diet and Nutrients that support detoxification
Inhibition of detoxifying enzymes
Essential Readings: 
1. Rao, K.R. (1986) Textbook of Biochemistry, III Edition. Prentice Hall of India Pvt. Ltd., New Delhi.
2. Murray, R.K. Granner, P.A. Mayes, V.W. Rodwell (1988) Harper’s Biochemistry. 21st Edition. Prentice Hall of Australia Pvt. Ltd.
3. Lehninger, A.L. (1987) Principles of Bio-chemistry – CBS Publishers and Distributors
4. West, E.S. Todd W.R. Mason, H.S. and Van Bruggen J.T (1974) 4th Ed. Text Book of Biochemistry, Amerind Publishing Co. Pvt. Ltd.
5. Harper, H.A. Review of Physiological Chemistry. Lange medical Library
6. White, A., Handler, P. and Smith, E.L. Principles of Biochemistry . W. B. Saunders Book Co. Philadelphia.
 
References: 
1. Berg, Jeremy Mark, Tymoczko, John L and Stryer. (2002). Biochemistry 5th ed. New York. W.H. Freeman and Co.
2. Brody Tom. (2004). Nutritional Biochemistry 2nd ed. New Delhi. Elsevier/Reed. Elsevier. India Pvt. Ltd.
3. Chatterjee, M.N. Shinde and Rana. (2005). Textbook of Medical Biochemistry, 6th ed. New Delhi, Jaypee Brothers. Medical Publisher.
4. Dandekar Sucheta P. (2002). Medical Biochemistry (Prep Manual for U.G.) 2nd ed. New Delhi B-1 Churchill Livingstone Pvt. Ltd.
5. Rastogi S.C. (1993). Biochemistry New Delhi, Tata McGraw Hill Publishing Co. Ltd.Definition, classification of lipids. Simple, Compound and derived
6. Kahn Conn, E.E. and Stump, P.K. Outlines of Biochemistry. Willey Eastern Pvt. Ltd. New Delhi 
7. Stryer L. (1995) Biochemistry Freeman WH & Co.
8. Sundararaj, P and Siddhu A (1995) Qualitative tests and Quantitative Procedures in Biochemsitry.
9. Varley H. Gowenlock, A.H. and Bell, M (1980) 5th Ed. Practical and Clinical Chemistry Vol. I William Heinemann Medical Book Ltd.
 
Academic Year: 
2014-2015
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