ADVANCED NUTRITIONAL BIOCHEMISTRY II (THEORY

Paper Code: 
HFN 221
Credits: 
3
Contact Hours: 
45.00
Max. Marks: 
100.00
Objective: 

Course Objectives:

This course will enable the students to –

 

  1. Understand the biochemical role of vitamins and minerals and their disorders and imbalances.
  2. Understand toxicity in the body and role of antioxidants in detoxification of the body.

 

Course Learning Outcomes (COs):

 

Course

Learning outcomes

(at course level)

Learning and teaching strategies

Assessment

Strategies

Paper Code

Paper Title

 

 

 

 

 

 

HFN  221

Advanced Nutritional Biochemistry -  II

(Theory)

 

 

 

 

 

The students will be able to –

COFN34: Develop skills in understanding the biochemistry of DNA and RNA and the application knowledge of purine and pyrimidine metabolism and their management.

 

COFN35: Develop skills in planning the diets as to consider the biochemical functions of various micronutrients

 

COFN36: Detoxification of various compounds and the knowledge of xenobiotics and its practical application for the management of various diseases. 

 

Approach in teaching:

Interactive Lectures, Discussion, Power Point Presentations, Informative videos, group discussion

 

Learning activities for the students:

Self learning assignments, Effective questions, presentations, Field trips

 

 

Quiz, Poster Presentations,

Power Point Presentations, Individual and group projects,

Open Book Test, Semester End Examination, discussion, demonstration

 

 

 

 

9.00
Unit I: 
UNIT I

Nucleic acid Chemistry              

  • Structures of purines, pyrimidines, Nucleocides, Nucleotides,
  •  Metabolism of Purine and Pyrimidine,
  •  Disorders of purine metabolism
  • Composition, classification, structure and properties of DNA and RNA; functions of nucleic acids - DNA  replication and  RNA transcription.  

 

 

9.00
Unit II: 
UNIT II

Hormones

  • Definition, classification, mode of action, Chemistry and functions of Thyroxine, Insulin, Catecholamines
  • Disorders associated with the hormones
  • Antioxidants
  • Antioxidants and free radicals; role of O2 free radicals; production of O2 free radicals; physiological mechanisms to limit free radical damage; free radical in human pathology and disease.
  •  

 

9.00
Unit III: 
UNIT III

Vitamins

  • Classification and Biochemical role of vitamins –
  • Fat soluble vitamins A, D, E, K, C and B-complex.
  • Water soluble vitamins B1,B2,B3,B6,B12,Pantothenic acid,

 

 

9.00
Unit IV: 
UNIT IV

Minerals

  • Biochemical roles 0f
  • Macro minerals: Calcium, Phosporous, magnesium, sodium, potassium and chloride
  • Micro Minerals: Iron, copper, zinc, manganese, iodine, fluoride
  • Trace Minerals: Selenium, cobalt, chromium, vanadium, silicon, nickel

 

 

9.00
Unit V: 
UNIT V
  • Detoxification of Foreign Compounds - metabolism of xenobiotics
  • Phase I, Phase II and Phase III
  • Regulation of detoxification
  • Diet and Nutrients that support detoxification
  • Inhibition of detoxifying enzymes

 

Essential Readings: 
  • Rao, K.R. (1986) Textbook of Biochemistry, III Edition. Prentice Hall of India Pvt. Ltd., New Delhi.
  • Murray, R.K. Granner, P.A. Mayes, V.W. Rodwell (1988) Harper’s Biochemistry. 21st Edition. Prentice Hall of Australia Pvt. Ltd.
  • Lehninger, A.L. (1987) Principles of Bio-chemistry – CBS Publishers and Distributors
  • West, E.S. Todd W.R. Mason, H.S. and Van Bruggen J.T (1974) 4th Ed. Text Book of Biochemistry, Amerind Publishing Co. Pvt. Ltd.
  • Harper, H.A. Review of Physiological Chemistry. Lange medical Library
  • White, A., Handler, P. and Smith, E.L. Principles of Biochemistry . W. B. Saunders Book Co. Philadelphia.

 

References: 
  • Berg, Jeremy Mark, Tymoczko, John L and Stryer. (2002). Biochemistry 5th ed. New York. W.H. Freeman and Co.
  • Brody Tom. (2004). Nutritional Biochemistry 2nd ed. New Delhi. Elsevier/Reed. Elsevier. India Pvt. Ltd.
  • Chatterjee, M.N. Shinde and Rana. (2005). Textbook of Medical Biochemistry, 6th ed. New Delhi, Jaypee Brothers. Medical Publisher.
  • DandekarSucheta P. (2002). Medical Biochemistry (Prep Manual for U.G.) 2nd ed. New Delhi B-1 Churchill Livingstone Pvt. Ltd.
  • Rastogi S.C. (1993). Biochemistry New Delhi, Tata McGraw Hill Publishing Co. Ltd.Definition, classification of lipids. Simple, Compound and derived
  • Kahn Conn, E.E. and Stump, P.K. Outlines of Biochemistry. Willey Eastern Pvt. Ltd. New Delhi
  • Stryer L. (1995) Biochemistry Freeman WH & Co.
  • Sundararaj, P and Siddhu A (1995) Qualitative tests and Quantitative Procedures in Biochemsitry.
  • Varley H. Gowenlock, A.H. and Bell, M (1980) 5th Ed. Practical and Clinical Chemistry Vol. I William Heinemann Medical Book Ltd.
  •  

 

Academic Year: 
2020-2021
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