ADVANCED NUTRITIONAL BIOCHEMISTRY II

Paper Code: 
HFN 221
Credits: 
03
Contact Hours: 
45.00
Max. Marks: 
100.00
Objective: 

This course will enable the students to –

1.     Understand the biochemical role of vitamins and minerals and their disorders and imbalances.

2.     Understand toxicity in the body and role of antioxidants in detoxification of the body.

Course outcomes

(at course level)

Learning and teaching strategies

Assessment

Strategies

  
 

The students will be able to –

COFN 32: Demonstrate the biochemistry of DNA and RNA and the metabolism of purine and pyrimidine metabolism and their management.

COFN 33:Show skills in planning the diets as to consider the biochemical functions of various micronutrients.

COFN 34:Detoxification of various compounds and the knowledge of xenobiotics and its practical application for the management of various diseases.

Approach in teaching:

Interactive Lectures, Discussion, Power Point Presentations, Informative videos, group discussion

 

Learning activities for the students:

Self learning assignments, Effective questions, presentations, Field trips

 

 

Quiz, Poster Presentations,

Power Point Presentations, Individual and group projects,

Open Book Test, Semester End Examination, discussion, demonstration

 

 

 

  
 

 

9.00

Unit I: Nucleic acid Chemistry

·       Composition, classification of purines, pyrimidines, Nucleosides, Nucleotides,

·       Structure and properties of DNA and RNA

·       Functions of  DNA and RNA

·        DNA replication, RNA transcription and translation.  

·       Mutations – Basic concept

·       Genetic Disorders

9.00

Unit II: Hormones  

·       Definition, classification, mode of action, Chemistry and functions of Thyroxine, Insulin, Catecholamines

·       Disorders associated with the hormones – Thyroxine, Insulin and catecholamines

·       Homeostasis of blood glucose

·       Hormones related to PCOS

·       Endocrine causes of hypertension

9.00

Unit III: Antioxidants and Vitamins       

  • ·       Antioxidants

      Antioxidants and free radicals; role of O2 free radicals; production of O2 free radicals; physiological mechanisms to limit free radical damage; free radical in human pathology and disease.

  •        Classification and Biochemical roles of vitamins –
  •        Fat soluble vitamins - A, D, E, K
  •       Water soluble vitamins B1,B2,B3,B6,B12,Pantothenic acid 
9.00

Unit IV: Minerals                                                                                       

     Biochemical roles of

·       Macro minerals: Calcium, phosphorous, magnesium, sodium, potassium and chloride

·       Micro Minerals: Iron, copper, zinc, manganese, iodine, fluoride

·       Trace Minerals: Selenium, cobalt, chromium, vanadium, silicon, nickel

9.00

Unit V: Detoxification of Foreign Compounds - metabolism of xenobiotics  

·       Phase I, Phase II and Phase III

·       Regulation of detoxification

·       Diet and Nutrients that support detoxification

·       Inhibition of detoxifying enzymes

Essential Readings: 

SUGGESTED BOOKS: 

·       Rao, K.R. (1986) Textbook of Biochemistry, III Edition. Prentice Hall of India Pvt. Ltd., New Delhi.

·       Murray, R.K. Granner, P.A. Mayes, V.W. Rodwell (1988) Harper’s Biochemistry. 21st Edition. Prentice Hall of Australia Pvt. Ltd.

·       Lehninger, A.L. (1987) Principles of Bio-chemistry – CBS Publishers and Distributors

·       West, E.S. Todd W.R. Mason, H.S. and Van Bruggen J.T (1974) 4th Ed. Text Book of Biochemistry, Amerind Publishing Co. Pvt. Ltd.

·       Harper, H.A. Review of Physiological Chemistry. Lange medical Library

·       White, A., Handler, P. and Smith, E.L. Principles of Biochemistry . W. B. Saunders Book Co. Philadelphia.

References: 

SUGGESTED REFERENCE BOOKS:

·       Berg, Jeremy Mark, Tymoczko, John L and Stryer. (2002). Biochemistry 5th ed. New York. W.H. Freeman and Co.

·       Brody Tom. (2004). Nutritional Biochemistry 2nd ed. New Delhi. Elsevier/Reed. Elsevier. India Pvt. Ltd.

·       Chatterjee, M.N. Shinde and Rana. (2005). Textbook of Medical Biochemistry, 6th ed. New Delhi, Jaypee Brothers. Medical Publisher.

·       DandekarSucheta P. (2002). Medical Biochemistry (Prep Manual for U.G.) 2nd ed. New Delhi B-1 Churchill Livingstone Pvt. Ltd.

·       Rastogi S.C. (1993). Biochemistry New Delhi, Tata McGraw Hill Publishing Co. Ltd.Definition, classification of lipids. Simple, Compound and derived

·       Kahn Conn, E.E. and Stump, P.K. Outlines of Biochemistry. Willey Eastern Pvt. Ltd. New Delhi

·       Stryer L. (1995) Biochemistry Freeman WH & Co.

·       Sundararaj, P and Siddhu A (1995) Qualitative tests and Quantitative Procedures in Biochemsitry.

·       Varley H. Gowenlock, A.H. and Bell, M (1980) 5th Ed. Practical and Clinical Chemistry Vol. I William Heinemann Medical Book Ltd.

 

e RESOURCE:

·       https://www.slideshare.net/YESANNA/mechanism-of-action-of-hormones-46154204

·       https://slideplayer.com/slide/5773843/ - Antioxidants

·       https://www.slideshare.net/YESANNA/detoxification-45599016

·       ttps://biochem.zsmu.zp.ua/wp-content/uploads/2017/04/biochemistry-of-vitamins.pdf

 

Journal: 

·       Journal of Nutritional Biochemistry

·       Journal of Clinical Biochemistry and Nutrition

·       Annual Review of Biochemistry

Academic Year: 
2023-2024
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