Nutritional Biochemistry I (Theory)

Paper Code: 
24DHFN711
Credits: 
04
Contact Hours: 
60.00
Max. Marks: 
100.00
Objective: 

This course will enable the students to –

  1. Understand the chemistry of macronutrients.
  2. Understand the mechanisms adopted by the human body for regulation of metabolic     pathways.
  3. Understand the interrelationships between various metabolic pathways.
Course Outcomes: 

Course

Course outcomes

(at course level)

Learning and teaching strategies

Assessment

Strategies

Course Code

Course Title

24DHFN 711

Nutritional Biochemistry I

 (Theory)

CO203:Appraise the chemistry and metabolism of carbohydrates

CO204:Classify proteins and elaborate systematically its metabolism

CO205:Explain the chemistry of lipids, its metabolism and associated disorders

CO206:Elaborate the types, action and activities of enzymes and their diagnostic role

CO207: Discuss biological oxidation, ETC and acid base balance

CO208:Contribute effectively in

course-specific interaction

Approach in teaching:

Interactive Lectures, Discussion, Power Point Presentations, Informative videos, group discussion

 

Learning activities for the students:

Self learning assignments, Effective questions, presentations, Field trips

Quiz, Poster Presentations,

Power Point Presentations, Individual and group projects,

Open Book Test, Semester End Examination, discussion, demonstration

 

 

12.00
Unit I: 
Introduction to Biomolecules
  • Types of chemical bonds, significance of asymmetric C atom
  • Carbohydrates Chemistry
    • Classification, structure and functions of carbohydrates
    • Properties of carbohydrates- Physical and chemical
  • Carbohydrate Metabolism Reactions of EMP, TCA (with structures), HMP, Gluconeogenesis (no structures), Glycogen metabolism (no structures),
12.00
Unit II: 
Protein Chemistry

●        Classification, structure and functions of amino acids and protein

●        Properties of Protein- Physical and Chemical

●        Plasma proteins – Nature, properties and functions

●        Protein metabolism

●        General reactions of amino acids- transamination, deamination and decarboxylation

●        Detoxification of NH3

  • Krebs-Hensleit cycle, Creatinine and creatine synthesis
12.00
Unit III: 
Lipid Chemistry

●        Classification, structures and functions of lipids

●        Properties of Lipids –Physical and Chemical

●        Structure and functions of Cholesterol

●        Lipid Metabolism

●        Knoop’s β-oxidation of even C fatty acid (no structures), ketone body formation and utilization

●        Fatty acid biosynthesis of Palmitic acid (no structure)

●        Metabolism of Cholesterol

  • Lipid storage disorders
12.00
Unit IV: 
Enzyme Chemistry
  • Definition, classification IUB (up to 1 digit), Concept of active site Enzyme specificity,     Units: Katal, IU, Factors affecting enzyme activity
  • Definition of Km and significance
  • Enzyme inhibition: Definition of Holoenzyme, Coenzyme, cofactor, Allosteric
  • site, active site, prosthetic group, isoenzyme
  • Mechanism of enzyme action
  • Diagnostic importance of enzymes
12.00
Unit V: 
Biological Oxidation
  • Electron transport chain; O-R potential; oxidative phosphorylation; enzymes of biological oxidation; inhibition of respiratory chain and oxidative phosphorylation.
  • Acid-Base balance, Buffers: definition, types of buffers, Role of lungs, kidneys and haemoglobin in Acid-Base balance Chloride shift
  • Regulation of acid base balance
  • Disorders of Acid-Base imbalance-acidosis & alkalosis –symptoms, causes, diagnosis,   treatment & complications

 

Essential Readings: 
  • Rao, K.R. (1986) Textbook of Biochemistry, III Edition. Prentice Hall of India Pvt. Ltd.,   New Delhi.
  • Murray, R.K. Granner, P.A. Mayes, V.W. Rodwell (1988) Harper’s Biochemistry. 21st        Edition. Prentice Hall of Australia Pvt. Ltd.
  • Lehninger, A.L. (1987) Principles of Bio-chemistry – CBS Publishers and Distributors
  • West, E.S. Todd W.R. Mason, H.S. and Van Bruggen J.T (1974) 4th Ed. Text Book of       Biochemistry, Amerind Publishing Co. Pvt. Ltd.
  • Satyanarayan U (2002) Biochemistry.Uppala author-publisher interlinks, Vijaywada.
References: 
  • White, A., Handler, P. and Smith, E.L. Principles of Biochemistry. W. B. Saunders Book Co. Philadelphia.
  • Kahn Conn, E.E. and Stump, P.K. Outlines of Biochemistry. Willey Eastern Pvt. Ltd. New Delhi
  • Murray, R.K., Granner, D.K., Mayes, P.A. and Rodwell, V.W. (2000): 25th Ed. Harpers Biochemistry. Macmillan Worth Publishers.
  •  Nelson, D.L. and Cox, M.M. (2000): 3rd Ed. Lehninger’s Principles Biochemistry, Macmillan Worth Publishers.
  • Devlin, T.M.d (1997): 4th Ed. Text book of Biochemistry with Clinical Correlations, WileLissInc
  • Stryer, L. (1998): 4th Ed. Biochemistry, WH Freeman and Co.
  • Conn, E.E., Stumpf, P.K., Bruening, G. and Doi, R.H. (2001): 5th Ed. Outlines of Biochemistry, John Wiley and Sons

 

Academic Year: 
2024-2025
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